Secretome & Proteomics

secretome

Hepatic Stellate Cell Secretome & Proteomics
Secretome : The secretome is the bulk of secreted organic molecules and inorganic components by biological cells, tissues, organs, and organisms. However, the term is usually referred as the secreted proteins of a proteome.
The concept of secretome is very critical to Hepatic Stellate Cell Biology as the HSC define sthe liver patho-physiology and pathologies by cross talking to other partners in the HSC microenvironment.
Proteomics: The gene expression profile is validated by using Mass Spectrometry. Identification of proteins in HSCs under the treatment of drugs is performed using ICP-MS.

REFERENCES

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2. Zhang H, Wu P, Chen F, Hao Y, Lao Y, Ren L, Sun L, Sun W, Wei H, Chan DW, Jiang Y, He F.SILAC-based quantitative proteomic analysis of secretome between activated and reverted hepatic stellate cells.Proteomics. 2014 Sep;14(17-18):1977-86.
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