Dr. Chatterjee was trained as a postdoctoral research fellow in Gastro-Intestinal Research Unit, specifically in the field of Hepatology in Prof. Vijay Shah’s laboratory, Mayo Clinic, Rochester, USA from 2000 to 2004. During this period, he worked on molecular regulation of eNOS and mechanisms of eNOS regulation in portal hypertension liver models.
2) Dr. S. Majumdar, AU-KBC Research Centre, Anna University visited the lab of Prof. J.F. Dufour, Hepatology, Department of Clinical Research, University of Bern.
3) Dr. Anne-Christine Piguet, Postdoctoral fellow, Hepatology, Department of Clinical Research visited the laboratory of Dr. Suvro Chatterjee, Faculty Scientist, AU-KBC Research Centre.
4) Prof.J.F.Dufour, Hepatology, Department of Clinical Research, University of Bern visited the lab of Dr.Suvro Chatterjee, Faculty Scientist, AU-KBC Research Centre three times during 1st international conference on angiogenesis, International workshop on Wound healing & Angiogenesis and 3rd international conference on angiogenesis.
5) Mr.Pavitra Kumar, a graduate student will be visiting Prof. J.F.Dufour’s lab during May-July 2016.
6) Dr.P.Gajalakshmi will be undertaking a visit to Prof.J.F. Dufour’s lab during June-Aug 2017.
The aim of the projects with Orchid Pharma was to study antifibrogenic activity of the given drug candidates on hepatic stellate cells. In chronic liver injury, activated stellate cells are the major source of the collagens that comprise fibrosis and cirrhosis. Drugs targeting the pathophysiology of activated stellate cells can be potential candidates for liver fibrosis. To study the therapeutic potential of the drug candidates on attenuating the pathological features of hepatic stellate cells, we have previously performed various fibrosis specific assays. We have tested collagen inhibitory activities of two anti-fibrogenesis drugs and compared with the effects of known anti-fibrogenesis drug using activated human hepatic stellate cell line.
1) Everolimus is a potent inhibitor of activated hepatic stellate cell functions in vitro and in vivo while demonstrating anti-angiogenic activities. (2013) Piguet A, Majumder S, Balaguru UM, Manjunathan R, Saran R, Chatterjee S, Dufour JF . Clinical Science. 126(11):775-84.
2) Study of the Cellular Mechanism of Sunitinib Mediated Inactivation of Activated Hepatic Stellate Cells and Its Implications in Angiogenesis (2013) Majumder S, Piguet A, Dufour JF, Chatterjee S. European Journal of Pharmacology. 705(1-3):86-95.
3) Defects in cGMP-PKG pathway contribute to impaired NO dependent relaxation in activated hepatic stellate cells (2006). Perri R, Langer DA, Chatterjee S, Gibbons SJ, Gadgil J, Farrugia G, Shah V (Am J Physiol Gastrointest Liver Physiol. 290(3):G535-42.
4) Mechanisms of nitric oxide interplay with Rho GTPase family members in modulation of actin membrane dynamics in pericytes and fibroblasts. (2005) Lee J.S., Decker NK, Chatterjee S, Yao J, Friedman S, Shah V Am J. Pathol. 166:1861-1870.
5) Influence of caveolin on a constitutively activated form of recombinant eNOS: Insights into eNOS dysfunction in the bile duct ligated liver. (2003) Hendrickson H, Chatterjee S, Cao M, Morales Ruiz M, Sessa WC, Shah V Am J Physiol Gastrointest Liver Physiol. 285:652-660.
6) Reversal of vasohibin driven negative feedback loop of VEGF-angiogenesis axis promises a novel anti-fibrotic therapeutic strategy for liver diseases (2014) Chatterjee S. Hepatology 60(2):458-60.
7) Simulated microgravity promoted differentiation of bipotential murine oval liver stem cells by modulating BMP4/Notch1 signaling. Majumder S, Siamwala JH, Srinivasan S, Sinha S, Sridhara SR, Soundararajan G, Seerapu HR, Chatterjee S. J Cell Biochem. 2011 Jul;112(7):1898-908.
8) Activated pericyte attenuates endothelial functions: Nitric oxide cGMP rescues activated pericyte associated endothelial dysfunctions. (2007) Majumder S, Tamilarasan KP, Kolluru GK, Muley A, Nair C M, Omanakuttan A, Murty KVGK and Chatterjee S. Biochem Cell Biol. 85 (6):709-20.
AUKBC Liver Research Projects:1) Study of the Cellular Mechanism of Sunitinib Mediated Inactivation of Activated Hepatic Stellate Cells and Its Implications in Angiogenesis DST Number: INT/SWISS/P-30/2009 Duration: 1st April 2009 till 31st March 2012.
2) Development and validation of a Cell-tissue co-culture model for aiding liver specific studies and drug discovery applications (Department of Biotechnology DBT 2012-2015)
3) Nitric oxide in hepatocellular carcinoma: mechanisms and therapeutic implications (DST 2015-2018). Indo-Swiss Joint Project.
4) Use of nitric oxide in reversing pathologic fibrogenesis in liver: A cell biology approach to cure liver cirrhosis (The Academy of Sciences for the Developing World – TWAS).
5) Antifibrotic effects of BACTIVATED HSC1015 and BACTIVATED HSC1237 on activated hepatic stellate cells. Orchid Pharma (2010-2011).
6) Targeting of antifibrogenic agents to hepatic stellate cells (HSC): A pilot consultancy project involving two drug candidates. Orchid Pharma (2010).
Conferences and Workshops Organized
1) International Conference on Molecular Signalling: 11-13 January 2017 Chennai
2) 1st Angiogenesis India: 1st International Conference on Angiogenesis
A strongly networked initiative in angiogenesis and microenvironment in India culminated in the highly successful event “International Conference on Angiogenesis: Basics and Applications” Chennai, 1-3 March 2012, was the first ever conference in the field of Angiogenesis to be held in the Asian region.
3) 2nd Angiogenesis India
Worked actively with NCCS, Pune and KIIT, Bhubaneshwar to host the 2nd Angiogenesis Conference at KIIT in February 2014.
4) 3rd Angiogenesis India
Worked actively with Sastra University to host 3rd Angiogenesis Conference at Sastra University 26-28 September 2015.
5) International Workshop
Hosted Workshop on “Angiogenesis and Wound Healing” in Chennai during 14-15 December 2013 under European Union- Mari curie PEOPLE FP7 program.
6) India-UK Angiogenesis Meeting
Worked as co-convener with Aston University, Birmingham to host 1st India-UK Angiogenesis Meeting at Birmingham UK in December 2014.
7) Nitric Oxide Society of India
Dr. Chatterjee is also the founder member of the Society for Nitric Oxide and Allied Radicals and is involved in formulating the strategy, plan and activities of the Society.
Working with International Consortium and Networks
1) The RUBICON Network: Training network for Research on molecUlar and Biomechanical Interactions in CONnective tissue disorders (RUBICON)
The Chatterjee Group has joined a worldwide network called RUBICON, funded by the European Commission (EC), for studying the pathology of tendons, cartilage, bone and blood vessels. The RUBICON Network project has nine other institutions from four continents as participants under the EC’s Horizon 2020 program, coordinated by the University of L’Aquila, Italy. The project involves 5 European institutions (the Universities of L’Aquila, Italy, Newcastle and Manchester, UK and Erasmus MC, Rotterdam, The Netherlands and Rigshospitalet, Glostrup, Copenhagen, Denmark) and 5 non-European (the University of Cape Town, South Africa, ICAHN School of Medicine at Mount Sinai, New York, USA, Anna University, Chennai, India and the University of Hong Kong, Hong Kong and the Australian Murdoch Children’s Research Institute). The RUBICON Network (Rubicon-network.org), presently envisaged for four years, will work to enhance understanding the pathology of connective tissue diseases and to identify new therapies. There will be exchanges of faculty and young researchers among the participating institutions to improve their interdisciplinary training so they develop an innovative research culture and create strong global partnerships and skill transfer mechanisms.
2) European Union – Marie Curie FP7 Project (2012-2015)
The interplay among bone cells, matrices and systems (INTERBONE) FP7-PEOPLE-2011-IRSES; Grant No 295181.
A group of six laboratories from six nations across the globe participated in this research initiative. The objective of the project was to investigate into the cross talk among bone cells, matrices and other physiological components. Several exchanges of scholars happened under this program and the results of the research work done under this program are under publication process.
The following link shows Dr.Chatterjee’s publications.